Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus

Calcium (Ca(2+)) is an essential second messenger required for diverse signaling processes in immune cells. Ca(2+) release-activated Ca(2+) (CRAC) channels represent one main Ca(2+) entry pathway into the cell. They are fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1)...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Derler, Isabella, Butorac, Carmen, Krizova, Adéla, Stadlbauer, Michael, Muik, Martin, Fahrner, Marc, Frischauf, Irene, Romanin, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787803/
https://ncbi.nlm.nih.gov/pubmed/29237734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812206
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