A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location

The search for antiprion compounds has been encouraged by the fact that transmissible spongiform encephalopathies (TSEs) share molecular mechanisms with more prevalent neurodegenerative pathologies, such as Parkinson's and Alzheimer's diseases. Cellular prion protein (PrP(C)) conversion in...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Ferreira, N. C., Ascari, L. M., Hughson, A. G., Cavalheiro, G. R., Góes, C. F., Fernandes, P. N., Hollister, J. R., da Conceição, R. A., Silva, D. S., Souza, A. M. T., Barbosa, M. L. C., Lara, F. A., Martins, R. A. P., Caughey, B., Cordeiro, Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786768/
https://ncbi.nlm.nih.gov/pubmed/29133563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01441-17
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