A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location

The search for antiprion compounds has been encouraged by the fact that transmissible spongiform encephalopathies (TSEs) share molecular mechanisms with more prevalent neurodegenerative pathologies, such as Parkinson's and Alzheimer's diseases. Cellular prion protein (PrP(C)) conversion in...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Ferreira, N. C., Ascari, L. M., Hughson, A. G., Cavalheiro, G. R., Góes, C. F., Fernandes, P. N., Hollister, J. R., da Conceição, R. A., Silva, D. S., Souza, A. M. T., Barbosa, M. L. C., Lara, F. A., Martins, R. A. P., Caughey, B., Cordeiro, Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786768/
https://ncbi.nlm.nih.gov/pubmed/29133563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01441-17
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