Cyclic Tetrapyrrole Sulfonation, Metals, and Oligomerization in Antiprion Activity

Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associat...

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Bibliographic Details
Main Authors: Caughey, Winslow S., Priola, Suzette A., Kocisko, David A., Raymond, Lynne D., Ward, Anne, Caughey, Byron
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151414/
https://ncbi.nlm.nih.gov/pubmed/17709470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01599-06
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