Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

A central aspect of pathogenesis in the transmissible spongiform encephalopathies or prion diseases is the conversion of normal protease-sensitive prion protein (PrP-sen) to the abnormal protease-resistant form, PrP-res. Here we identify porphyrins and phthalocyanines as inhibitors of PrP-res accumu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Caughey, Winslow S., Raymond, Lynne D., Horiuchi, Motohiro, Caughey, Byron
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22794/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9770449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.21.12117
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