Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine

Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell proliferation. We evaluated the effect of TSA on HDAC expression, tumor cell proliferation, and cancer stem cells (CSCs) activities in pancreati...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Cai, Mao-Hua, Xu, Xiao-Gang, Yan, Shi-Li, Sun, Ze, Ying, Yin, Wang, Bai-Kui, Tu, Yue-Xing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786009/
https://ncbi.nlm.nih.gov/pubmed/29374219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20004-0
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