Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine

Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell proliferation. We evaluated the effect of TSA on HDAC expression, tumor cell proliferation, and cancer stem cells (CSCs) activities in pancreati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cai, Mao-Hua, Xu, Xiao-Gang, Yan, Shi-Li, Sun, Ze, Ying, Yin, Wang, Bai-Kui, Tu, Yue-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786009/
https://ncbi.nlm.nih.gov/pubmed/29374219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20004-0
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