Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib

Quiescent leukemia stem cells (LSCs) that are insensitive to BCR-ABL tyrosine kinase inhibitors confer resistance to imatinib in chronic myelogenous leukemia (CML). Identifying proteins to regulate survival and stemness of LSCs is urgently needed. Although histone deacetylase inhibitors (HDACis) can...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Jin, Yanli, Yao, Yiwu, Chen, Li, Zhu, Xiaohui, Jin, Bei, Shen, Yingying, Li, Juan, Du, Xin, Lu, Yuhong, Jiang, Sheng, Pan, Jingxuan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997248/
https://ncbi.nlm.nih.gov/pubmed/27570562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.16139
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