Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureus

Mutations in the beta-subunit of bacterial RNA polymerase (RpoB) cause resistance to rifampin (Rif(r)), a critical antibiotic for treatment of multidrug-resistant Staphylococcus aureus. In vitro studies have shown that RpoB mutations confer decreased susceptibility to other antibiotics, but the clin...

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Publicat a:mSphere
Autors principals: Guérillot, Romain, Gonçalves da Silva, Anders, Monk, Ian, Giulieri, Stefano, Tomita, Takehiro, Alison, Eloise, Porter, Jessica, Pidot, Sacha, Gao, Wei, Peleg, Anton Y., Seemann, Torsten, Stinear, Timothy P., Howden, Benjamin P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784246/
https://ncbi.nlm.nih.gov/pubmed/29404415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00550-17
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