Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections

Staphylococcus aureus small-colony variants (SCVs) are associated with unusually chronic and persistent infections despite active antibiotic treatment. The molecular basis for this clinically important phenomenon is poorly understood, hampered by the instability of the SCV phenotype. Here we investi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Guérillot, Romain, Kostoulias, Xenia, Donovan, Liam, Li, Lucy, Carter, Glen P., Hachani, Abderrahman, Vandelannoote, Koen, Giulieri, Stefano, Monk, Ian R., Kunimoto, Mayu, Starrs, Lora, Burgio, Gaétan, Seemann, Torsten, Peleg, Anton Y., Stinear, Timothy P., Howden, Benjamin P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6778178/
https://ncbi.nlm.nih.gov/pubmed/31527262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904861116
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