RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, the causal mutation for 17 neurological diseases. Increased expansion frequ...

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Publicado en:Cell Rep
Main Authors: Frizzell, Aisling, Nguyen, Jennifer H.G., Petalcorin, Mark I.R., Turner, Katherine D., Boulton, Simon J., Freudenreich, Catherine H., Lahue, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783307/
https://ncbi.nlm.nih.gov/pubmed/24561255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.034
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