MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington’s disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. For example, the DNA repair complex MutSβ (MSH2–MSH3 heterodimer) is require...

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Bibliographic Details
Main Authors: Gannon, Anne-Marie M., Frizzell, Aisling, Healy, Evan, Lahue, Robert S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488247/
https://ncbi.nlm.nih.gov/pubmed/22941650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks810
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