Autonomous generation and loading of DNA guides by bacterial Argonaute

Several prokaryotic Argonaute proteins (pAgos) utilize small DNA guides to mediate host defense by targeting invading DNA complementary to the DNA guide. It is unknown how these DNA guides are being generated and loaded onto pAgo. Here we demonstrate that guide-free Argonaute from Thermus thermophil...

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Publicat a:Mol Cell
Autors principals: Swarts, Daan C., Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D., Zhu, Yifan, Timmers, Elizabeth M., Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779613/
https://ncbi.nlm.nih.gov/pubmed/28262506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.033
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