Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage

We report on crystal structures of ternary Thermus thermophilus Argonaute (TtAgo) complexes with 5′-phosphorylated guide DNA and a series of DNA targets. These ternary complex structures of cleavage-incompatible, cleavage-compatible, and postcleavage states solved at improved resolution up to 2.2 Å...

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Bibliografske podrobnosti
Main Authors: Sheng, Gang, Zhao, Hongtu, Wang, Jiuyu, Rao, Yu, Tian, Wenwen, Swarts, Daan C., van der Oost, John, Patel, Dinshaw J., Wang, Yanli
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896195/
https://ncbi.nlm.nih.gov/pubmed/24374628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321032111
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