Autonomous generation and loading of DNA guides by bacterial Argonaute

Several prokaryotic Argonaute proteins (pAgos) utilize small DNA guides to mediate host defense by targeting invading DNA complementary to the DNA guide. It is unknown how these DNA guides are being generated and loaded onto pAgo. Here we demonstrate that guide-free Argonaute from Thermus thermophil...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Swarts, Daan C., Szczepaniak, Malwina, Sheng, Gang, Chandradoss, Stanley D., Zhu, Yifan, Timmers, Elizabeth M., Zhang, Yong, Zhao, Hongtu, Lou, Jizhong, Wang, Yanli, Joo, Chirlmin, van der Oost, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779613/
https://ncbi.nlm.nih.gov/pubmed/28262506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.033
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