Matrine‐Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species‐Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling

BACKGROUND: The matrine‐type alkaloids are bioactive components extracted from Sophora flavescens, which is used in treatment of diabetes mellitus in traditional Chinese medicine. Advanced glycation end products mediate diabetic vascular complications. This study was aimed to investigate the protect...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Liu, Zhongwei, Lv, Ying, Zhang, Yong, Liu, Fuqiang, Zhu, Ling, Pan, Shuo, Qiu, Chuan, Guo, Yan, Yang, Tielin, Wang, Junkui
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779049/
https://ncbi.nlm.nih.gov/pubmed/29197828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007441
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