Matrine‐Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species‐Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling

BACKGROUND: The matrine‐type alkaloids are bioactive components extracted from Sophora flavescens, which is used in treatment of diabetes mellitus in traditional Chinese medicine. Advanced glycation end products mediate diabetic vascular complications. This study was aimed to investigate the protect...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Liu, Zhongwei, Lv, Ying, Zhang, Yong, Liu, Fuqiang, Zhu, Ling, Pan, Shuo, Qiu, Chuan, Guo, Yan, Yang, Tielin, Wang, Junkui
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779049/
https://ncbi.nlm.nih.gov/pubmed/29197828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007441
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