E-motif formed by extrahelical cytosine bases in DNA homoduplexes of trinucleotide and hexanucleotide repeats

Atypical DNA secondary structures play an important role in expandable trinucleotide repeat (TR) and hexanucleotide repeat (HR) diseases. The cytosine mismatches in C-rich homoduplexes and hairpin stems are weakly bonded; experiments show that for certain sequences these may flip out of the helix co...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Pan, Feng, Zhang, Yuan, Man, Viet Hoang, Roland, Christopher, Sagui, Celeste
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Structural Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778509/
https://ncbi.nlm.nih.gov/pubmed/29190385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1186
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