Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich’s ataxia: DNA triplexes and RNA/DNA hybrids

Expansion of the GAA/TTC repeats in the first intron of the FXN gene causes Friedreich’s ataxia. Non-canonical structures are linked to this expansion. DNA triplexes and R-loops are believed to arrest transcription, which results in frataxin deficiency and eventual neurodegeneration. We present a sy...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Zhang, Jiahui, Fakharzadeh, Ashkan, Pan, Feng, Roland, Christopher, Sagui, Celeste
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515735/
https://ncbi.nlm.nih.gov/pubmed/32821947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa665
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