Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

Prokaryotes encode various host defense systems that provide protection against mobile genetic elements. Restriction–modification (R–M) and CRISPR–Cas systems mediate host defense by sequence specific targeting of invasive DNA. T-even bacteriophages employ covalent modifications of nucleobases to av...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Vlot, Marnix, Houkes, Joep, Lochs, Silke J A, Swarts, Daan C, Zheng, Peiyuan, Kunne, Tim, Mohanraju, Prarthana, Anders, Carolin, Jinek, Martin, van der Oost, John, Dickman, Mark J, Brouns, Stan J J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Nucleic Acid Enzymes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778469/
https://ncbi.nlm.nih.gov/pubmed/29253268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1264
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