Llwytho...
Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease activity for processing its own guide RNAs, and RNA-guided DNase activity for target DNA cleavage. To elucidate the molecular basis of both activiti...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Cell |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2017
|
| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6879319/ https://ncbi.nlm.nih.gov/pubmed/28431230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.016 |
| Tagiau: |
Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|