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Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease activity for processing its own guide RNAs, and RNA-guided DNase activity for target DNA cleavage. To elucidate the molecular basis of both activiti...
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| Опубликовано в: : | Mol Cell |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6879319/ https://ncbi.nlm.nih.gov/pubmed/28431230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.016 |
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