Llwytho...

Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a

The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease activity for processing its own guide RNAs, and RNA-guided DNase activity for target DNA cleavage. To elucidate the molecular basis of both activiti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Swarts, Daan C., van der Oost, John, Jinek, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879319/
https://ncbi.nlm.nih.gov/pubmed/28431230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.016
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