Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

Prokaryotes encode various host defense systems that provide protection against mobile genetic elements. Restriction–modification (R–M) and CRISPR–Cas systems mediate host defense by sequence specific targeting of invasive DNA. T-even bacteriophages employ covalent modifications of nucleobases to av...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Vlot, Marnix, Houkes, Joep, Lochs, Silke J A, Swarts, Daan C, Zheng, Peiyuan, Kunne, Tim, Mohanraju, Prarthana, Anders, Carolin, Jinek, Martin, van der Oost, John, Dickman, Mark J, Brouns, Stan J J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778469/
https://ncbi.nlm.nih.gov/pubmed/29253268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1264
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