Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. Pancreatic cancer development and metastasis occur in complex settings, with reciprocal feedback from microenvironmental c...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Vennin, Claire, Chin, Venessa T., Warren, Sean C., Lucas, Morghan C., Herrmann, David, Magenau, Astrid, Melenec, Pauline, Walters, Stacey N., del Monte-Nieto, Gonzalo, Conway, James R. W., Nobis, Max, Allam, Amr H., McCloy, Rachael A., Currey, Nicola, Pinese, Mark, Boulghourjian, Alice, Zaratzian, Anaiis, Adam, Arne A. S., Heu, Celine, Nagrial, Adnan M., Chou, Angela, Steinmann, Angela, Drury, Alison, Froio, Danielle, Giry-Laterriere, Marc, Harris, Nathanial L. E., Phan, Tri, Jain, Rohit, Weninger, Wolfgang, McGhee, Ewan J., Whan, Renee, Johns, Amber L, Samra, Jaswinder S., Chantrill, Lorraine, Gill, Anthony J., Kohonen-Corish, Maija, Harvey, Richard P., Biankin, Andrew V., Jeffry Evans, T. R., Anderson, Kurt I., Grey, Shane T., Ormandy, Christopher J., Gallego-Ortega, David, Wang, Yingxiao, Samuel, Michael S., Sansom, Owen J., Burgess, Andrew, Cox, Thomas R., Morton, Jennifer P., Pajic, Marina, Timpson, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777504/
https://ncbi.nlm.nih.gov/pubmed/28381539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai8504
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