Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. Pancreatic cancer development and metastasis occur in complex settings, with reciprocal feedback from microenvironmental c...

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Published in:Sci Transl Med
Main Authors: Vennin, Claire, Chin, Venessa T., Warren, Sean C., Lucas, Morghan C., Herrmann, David, Magenau, Astrid, Melenec, Pauline, Walters, Stacey N., del Monte-Nieto, Gonzalo, Conway, James R. W., Nobis, Max, Allam, Amr H., McCloy, Rachael A., Currey, Nicola, Pinese, Mark, Boulghourjian, Alice, Zaratzian, Anaiis, Adam, Arne A. S., Heu, Celine, Nagrial, Adnan M., Chou, Angela, Steinmann, Angela, Drury, Alison, Froio, Danielle, Giry-Laterriere, Marc, Harris, Nathanial L. E., Phan, Tri, Jain, Rohit, Weninger, Wolfgang, McGhee, Ewan J., Whan, Renee, Johns, Amber L, Samra, Jaswinder S., Chantrill, Lorraine, Gill, Anthony J., Kohonen-Corish, Maija, Harvey, Richard P., Biankin, Andrew V., Jeffry Evans, T. R., Anderson, Kurt I., Grey, Shane T., Ormandy, Christopher J., Gallego-Ortega, David, Wang, Yingxiao, Samuel, Michael S., Sansom, Owen J., Burgess, Andrew, Cox, Thomas R., Morton, Jennifer P., Pajic, Marina, Timpson, Paul
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777504/
https://ncbi.nlm.nih.gov/pubmed/28381539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai8504
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