Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. Pancreatic cancer development and metastasis occur in complex settings, with reciprocal feedback from microenvironmental c...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Vennin, Claire, Chin, Venessa T., Warren, Sean C., Lucas, Morghan C., Herrmann, David, Magenau, Astrid, Melenec, Pauline, Walters, Stacey N., del Monte-Nieto, Gonzalo, Conway, James R. W., Nobis, Max, Allam, Amr H., McCloy, Rachael A., Currey, Nicola, Pinese, Mark, Boulghourjian, Alice, Zaratzian, Anaiis, Adam, Arne A. S., Heu, Celine, Nagrial, Adnan M., Chou, Angela, Steinmann, Angela, Drury, Alison, Froio, Danielle, Giry-Laterriere, Marc, Harris, Nathanial L. E., Phan, Tri, Jain, Rohit, Weninger, Wolfgang, McGhee, Ewan J., Whan, Renee, Johns, Amber L, Samra, Jaswinder S., Chantrill, Lorraine, Gill, Anthony J., Kohonen-Corish, Maija, Harvey, Richard P., Biankin, Andrew V., Jeffry Evans, T. R., Anderson, Kurt I., Grey, Shane T., Ormandy, Christopher J., Gallego-Ortega, David, Wang, Yingxiao, Samuel, Michael S., Sansom, Owen J., Burgess, Andrew, Cox, Thomas R., Morton, Jennifer P., Pajic, Marina, Timpson, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777504/
https://ncbi.nlm.nih.gov/pubmed/28381539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai8504
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