Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure

AIMS: Inflammation and organ failure have been reported to have an impact on cytochrome P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to evaluate a previously developed population pharmacokinetic model both in critically ill children and other populations, in...

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Udgivet i:Br J Clin Pharmacol
Main Authors: Brussee, Janneke M., Vet, Nienke J., Krekels, Elke H. J., Valkenburg, Abraham J., Jacqz‐Aigrain, Evelyne, van Gerven, Joop M. A., Swart, Eleonora L., van den Anker, Johannes N., Tibboel, Dick, de Hoog, Matthijs, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Paediatric Clinical Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777436/
https://ncbi.nlm.nih.gov/pubmed/29072785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13459
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