Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models

AIM: The objective of this investigation was to assess the performance of an allometric model as the basis for interpolating drug exposure in the context of pharmacokinetic bridging across paediatric subpopulations. METHODS: Midazolam was selected as a paradigm compound. Two nonlinear mixed effects...

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Detalhes bibliográficos
Main Authors: Cella, Massimo, Knibbe, Catherijne, de Wildt, Saskia N, Van Gerven, Joop, Danhof, Meindert, Della Pasqua, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Paediatric Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477354/
https://ncbi.nlm.nih.gov/pubmed/22300419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04206.x
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