Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models

AIM: The objective of this investigation was to assess the performance of an allometric model as the basis for interpolating drug exposure in the context of pharmacokinetic bridging across paediatric subpopulations. METHODS: Midazolam was selected as a paradigm compound. Two nonlinear mixed effects...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Cella, Massimo, Knibbe, Catherijne, de Wildt, Saskia N, Van Gerven, Joop, Danhof, Meindert, Della Pasqua, Oscar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2012
Konular:
Paediatric Clinical Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477354/
https://ncbi.nlm.nih.gov/pubmed/22300419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04206.x
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller