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Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?
AIMS: To assess the predictive value of a model-based approach for dose selection across paediatric populations in early clinical drug development. METHODS: Abacavir was selected as a paradigm compound using data across a wide age range. Abacavir pharmacokinetics (PK) in children were analysed separ...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175515/ https://ncbi.nlm.nih.gov/pubmed/21501213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03992.x |
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