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Covariate effects and population pharmacokinetics of lamivudine in HIV-infected children

AIM: Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive p...

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Bibliografski detalji
Glavni autori: Piana, Chiara, Zhao, Wei, Adkison, Kimberly, Burger, David, Jacqz-Aigrain, Evelyne, Danhof, Meindert, Della Pasqua, Oscar
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004406/
https://ncbi.nlm.nih.gov/pubmed/24118070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12247
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