Covariate effects and population pharmacokinetics of lamivudine in HIV-infected children

AIM: Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive p...

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Bibliographic Details
Main Authors: Piana, Chiara, Zhao, Wei, Adkison, Kimberly, Burger, David, Jacqz-Aigrain, Evelyne, Danhof, Meindert, Della Pasqua, Oscar
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
Subjects:
Paediatric Clinical Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004406/
https://ncbi.nlm.nih.gov/pubmed/24118070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12247
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