Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?

AIMS: To assess the predictive value of a model-based approach for dose selection across paediatric populations in early clinical drug development. METHODS: Abacavir was selected as a paradigm compound using data across a wide age range. Abacavir pharmacokinetics (PK) in children were analysed separ...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Cella, Massimo, Zhao, Wei, Jacqz-Aigrain, Evelyne, Burger, David, Danhof, Meindert, Pasqua, Oscar Della
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Science Inc 2011
נושאים:
Paediatric Clinical Pharmacology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175515/
https://ncbi.nlm.nih.gov/pubmed/21501213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03992.x
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