Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models

AIM: The objective of this investigation was to assess the performance of an allometric model as the basis for interpolating drug exposure in the context of pharmacokinetic bridging across paediatric subpopulations. METHODS: Midazolam was selected as a paradigm compound. Two nonlinear mixed effects...

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Main Authors: Cella, Massimo, Knibbe, Catherijne, de Wildt, Saskia N, Van Gerven, Joop, Danhof, Meindert, Della Pasqua, Oscar
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2012
Fag:
Paediatric Clinical Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477354/
https://ncbi.nlm.nih.gov/pubmed/22300419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04206.x
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