Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure

AIMS: Inflammation and organ failure have been reported to have an impact on cytochrome P450 (CYP) 3A‐mediated clearance of midazolam in critically ill children. Our aim was to evaluate a previously developed population pharmacokinetic model both in critically ill children and other populations, in...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Brussee, Janneke M., Vet, Nienke J., Krekels, Elke H. J., Valkenburg, Abraham J., Jacqz‐Aigrain, Evelyne, van Gerven, Joop M. A., Swart, Eleonora L., van den Anker, Johannes N., Tibboel, Dick, de Hoog, Matthijs, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Paediatric Clinical Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777436/
https://ncbi.nlm.nih.gov/pubmed/29072785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13459
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