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Lessons in PROTAC design from selective degradation with a promiscuous warhead
Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we report a previously understudied benefit of small molecule Proteolysis Targeting Chimera (PROTACs) that recruit E3 ubiquitin ligases to target proteins for their ubiquitination and subsequent proteasome-mediat...
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| Опубликовано в: : | Cell Chem Biol |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777153/ https://ncbi.nlm.nih.gov/pubmed/29129718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.010 |
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