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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulting in its targeted degradation. Many potent PROTACs with specificity for dissimilar targets have been developed; however, the factors governing degradati...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6328587/ https://ncbi.nlm.nih.gov/pubmed/30631068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08027-7 |
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