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Scaffold hopping enables direct access to more potent PROTACs with in vivo activity
Herein we employ a scaffold hopping approach to enhance the activity of a previously reported BCR-Abl PROTAC. This represents a significant advance in the PROTAC field since it can abrogate the need to optimize the linker to access a more potent degrader. The new PROTAC demonstrates a >10 fold in...
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| Udgivet i: | Chem Commun (Camb) |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7404552/ https://ncbi.nlm.nih.gov/pubmed/32519703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc02201b |
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