In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis

Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs. Her...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gautam, Uma S., Foreman, Taylor W., Bucsan, Allison N., Veatch, Ashley V., Alvarez, Xavier, Adekambi, Toidi, Golden, Nadia A., Gentry, Kaylee M., Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Didier, Peter J., Blanchard, James L., Kousoulas, K. Gus, Lackner, Andrew A., Kalman, Daniel, Rengarajan, Jyothi, Khader, Shabaana A., Kaushal, Deepak, Mehra, Smriti
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776797/
https://ncbi.nlm.nih.gov/pubmed/29255022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711373114
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