In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis

Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs. Her...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gautam, Uma S., Foreman, Taylor W., Bucsan, Allison N., Veatch, Ashley V., Alvarez, Xavier, Adekambi, Toidi, Golden, Nadia A., Gentry, Kaylee M., Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Didier, Peter J., Blanchard, James L., Kousoulas, K. Gus, Lackner, Andrew A., Kalman, Daniel, Rengarajan, Jyothi, Khader, Shabaana A., Kaushal, Deepak, Mehra, Smriti
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776797/
https://ncbi.nlm.nih.gov/pubmed/29255022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711373114
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