Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination approaches. Novel anti-TB vaccines are therefore urgently required. Here we show that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kaushal, Deepak, Foreman, Taylor W., Gautam, Uma S., Alvarez, Xavier, Adekambi, Toidi, Rangel-Moreno, Javier, Golden, Nadia A., Johnson, Ann-Marie F., Phillips, Bonnie L., Ahsan, Muhammad H., Russell-Lodrigue, Kasi E., Doyle, Lara A., Roy, Chad J., Didier, Peter J., Blanchard, James L., Rengarajan, Jyothi, Lackner, Andrew A., Khader, Shabaana A., Mehra, Smriti
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608260/
https://ncbi.nlm.nih.gov/pubmed/26460802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9533
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