The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence

Rationale: Hypoxia promotes dormancy by causing physiologic changes to actively replicating Mycobacterium tuberculosis. DosR controls the response of M. tuberculosis to hypoxia. Objectives: To understand DosR's contribution in the persistence of M. tuberculosis, we compared the phenotype of var...

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Veröffentlicht in:Am J Respir Crit Care Med
Hauptverfasser: Mehra, Smriti, Foreman, Taylor W., Didier, Peter J., Ahsan, Muhammad H., Hudock, Teresa A., Kissee, Ryan, Golden, Nadia A., Gautam, Uma S., Johnson, Ann-Marie, Alvarez, Xavier, Russell-Lodrigue, Kasi E., Doyle, Lara A., Roy, Chad J., Niu, Tianhua, Blanchard, James L., Khader, Shabaana A., Lackner, Andrew A., Sherman, David R., Kaushal, Deepak
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451619/
https://ncbi.nlm.nih.gov/pubmed/25730547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201408-1502OC
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