In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis

Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs. Her...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gautam, Uma S., Foreman, Taylor W., Bucsan, Allison N., Veatch, Ashley V., Alvarez, Xavier, Adekambi, Toidi, Golden, Nadia A., Gentry, Kaylee M., Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Didier, Peter J., Blanchard, James L., Kousoulas, K. Gus, Lackner, Andrew A., Kalman, Daniel, Rengarajan, Jyothi, Khader, Shabaana A., Kaushal, Deepak, Mehra, Smriti
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776797/
https://ncbi.nlm.nih.gov/pubmed/29255022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711373114
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