Design, synthesis, and biological evaluation of 6-methoxy-2-arylquinolines as potential P-glycoprotein inhibitors

OBJECTIVE(S): In the present study, a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. MATERIALS AND METHODS: The cytotoxic activity of the synthesized compounds was evaluated against...

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Bibliographic Details
Published in:Iran J Basic Med Sci
Main Authors: Aboutorabzadeh, Sayyed Mohammad, Mosaffa, Fatemeh, Hadizadeh, Farzin, Ghodsi, Razieh
Format: Artigo
Language:Inglês
Published: Mashhad University of Medical Sciences 2018
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776443/
https://ncbi.nlm.nih.gov/pubmed/29372031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/IJBMS.2017.21892.5616
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