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Design, Synthesis and Biological Evaluation of New 5,5-Diarylhydantoin Derivatives as Selective Cyclooxygenase-2 Inhibitors

A new group of 5,5-diarylhydantoin derivatives bearing a methylsulfonyl COX-2 pharmacophore at the para position of the C-5 phenyl ring were designed and synthesized as selective COX-2 inhibitors. In vitro COX-1/COX-2 inhibition structure-activity relationships identified 5-[4-(methylsulfonyl)phenyl...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zarghi, Afshin, Javid, Farin Sattary, Ghodsi, Razieh, Dadrass, Orkideh G., Daraei, Bahram, Hedayati, Mehdi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Österreichische Apotheker-Verlagsgesellschaft 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163375/
https://ncbi.nlm.nih.gov/pubmed/21886896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1104-20
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