Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives as Selective Cyclooxygenase-2 Inhibitors

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of a new group of 1, 4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO(2)Me pharmacophore at the para posit...

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Bibliographic Details
Published in:Iran J Pharm Res
Main Authors: Sabakhi, Iman, Topuzyan, Vigen, Hajimahdi, Zahra, Daraei, Bahram, Arefi, Hadi, Zarghi, Afshin
Format: Artigo
Language:Inglês
Published: Shaheed Beheshti University of Medical Sciences 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673936/
https://ncbi.nlm.nih.gov/pubmed/26664375
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