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Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors

In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity. In vitro COX-1/COX...

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Detalhes bibliográficos
Publicado no:Sci Pharm
Main Authors: Zarghi, Afshin, Kakhki, Samaneh
Formato: Artigo
Idioma:Inglês
Publicado em: The Austrian Journal of Pharmaceutical Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727773/
https://ncbi.nlm.nih.gov/pubmed/26839798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1407-20
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