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Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity
OBJECTIVE(S): In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitors MATERIALS AND METHODS: The cytotoxicity of the novel synthesized β-acetamidoketones was assessed against two cancerous cell lines including MCF-7 (human breas...
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| Publicado no: | Iran J Basic Med Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mashhad University of Medical Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6885397/ https://ncbi.nlm.nih.gov/pubmed/31998454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2019.34760.8242 |
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