Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity

OBJECTIVE(S): In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitors MATERIALS AND METHODS: The cytotoxicity of the novel synthesized β-acetamidoketones was assessed against two cancerous cell lines including MCF-7 (human breas...

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Publicado en:Iran J Basic Med Sci
Autores principales: Karimikia, Ehsan, Behravan, Javad, Zarghi, Afshin, Ghandadi, Morteza, Omid Malayeri, Sina, Ghodsi, Razieh
Formato: Artigo
Lenguaje:Inglês
Publicado: Mashhad University of Medical Sciences 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885397/
https://ncbi.nlm.nih.gov/pubmed/31998454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2019.34760.8242
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