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Induction of Human Cytochrome P450 3A Enzymes in Cultured Placental Cells by Thalidomide and Relevance to Bioactivation and Toxicity

Evidence has been presented for auto-induced human cytochrome P450 3A enzyme involvement in the teratogenicity and clinical outcome of thalidomide due to oxidation to 5-hydroxythalidomide and subsequent metabolic activation in livers. In this study, more relevant human placenta preparations and plac...

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Bibliografiske detaljer
Udgivet i:J Toxicol Sci
Main Authors: Murayama, Norie, Kazuki, Yasuhiro, Satoh, Daisuke, Arata, Kazuya, Harada, Tasuku, Shibata, Norio, Guengerich, F. Peter, Yamazaki, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776038/
https://ncbi.nlm.nih.gov/pubmed/28496040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2131/jts.42.343
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