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Induction of Human Cytochrome P450 3A Enzymes in Cultured Placental Cells by Thalidomide and Relevance to Bioactivation and Toxicity
Evidence has been presented for auto-induced human cytochrome P450 3A enzyme involvement in the teratogenicity and clinical outcome of thalidomide due to oxidation to 5-hydroxythalidomide and subsequent metabolic activation in livers. In this study, more relevant human placenta preparations and plac...
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| Publicado en: | J Toxicol Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5776038/ https://ncbi.nlm.nih.gov/pubmed/28496040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2131/jts.42.343 |
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