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SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation also play...
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| Publicado en: | Genome Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5775534/ https://ncbi.nlm.nih.gov/pubmed/29351814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1376-y |
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