SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation also play...

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Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Deniz, Özgen, de la Rica, Lorenzo, Cheng, Kevin C. L., Spensberger, Dominik, Branco, Miguel R.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775534/
https://ncbi.nlm.nih.gov/pubmed/29351814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1376-y
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