A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

BACKGROUND: Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Ramasamy, Viswanathan, Arora, Upasana, Shukla, Rahul, Poddar, Ankur, Shanmugam, Rajgokul K., White, Laura J., Mattocks, Melissa M., Raut, Rajendra, Perween, Ashiya, Tyagi, Poornima, de Silva, Aravinda M., Bhaumik, Siddhartha K., Kaja, Murali Krishna, Villinger, François, Ahmed, Rafi, Johnston, Robert E., Swaminathan, Sathyamangalam, Khanna, Navin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774828/
https://ncbi.nlm.nih.gov/pubmed/29309412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006191
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